Analysis of the coding genome of diffuse large B-cell lymphoma

作者: Laura Pasqualucci , Vladimir Trifonov , Giulia Fabbri , Jing Ma , Davide Rossi

DOI: 10.1038/NG.892

关键词: BiologyGenomeMalignancyGerminal centerDiffuse large B-cell lymphomaHuman genomeGeneCopy number analysisGene dosageGenetics

摘要: Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the pathogenesis of this …

参考文章(63)
Sietske A. Riemersma, Ekaterina S. Jordanova, Roelandt F. J. Schop, Katja Philippo, Leendert H. J. Looijenga, Ed Schuuring, Philip M. Kluin, Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites. Blood. ,vol. 96, pp. 3569- 3577 ,(2000) , 10.1182/BLOOD.V96.10.3569
Laura Pasqualucci, Peter Neumeister, Tina Goossens, Gouri Nanjangud, R. S. K. Chaganti, Ralf Küppers, Riccardo Dalla-Favera, Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas Nature. ,vol. 412, pp. 341- 346 ,(2001) , 10.1038/35085588
C. J. Sneeringer, M. P. Scott, K. W. Kuntz, S. K. Knutson, R. M. Pollock, V. M. Richon, R. A. Copeland, Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 20980- 20985 ,(2010) , 10.1073/PNAS.1012525107
Christina M. Annunziata, R. Eric Davis, Yulia Demchenko, William Bellamy, Ana Gabrea, Fenghuang Zhan, Georg Lenz, Ichiro Hanamura, George Wright, Wenming Xiao, Sandeep Dave, Elaine M. Hurt, Bruce Tan, Hong Zhao, Owen Stephens, Madhumita Santra, David R. Williams, Lenny Dang, Bart Barlogie, John D. Shaughnessy, W. Michael Kuehl, Louis M. Staudt, Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma Cancer Cell. ,vol. 12, pp. 115- 130 ,(2007) , 10.1016/J.CCR.2007.07.004
Andreas Rosenwald, George Wright, Wing C. Chan, Joseph M. Connors, Elias Campo, Richard I. Fisher, Randy D. Gascoyne, H. Konrad Muller-Hermelink, Erlend B. Smeland, Jena M. Giltnane, Elaine M. Hurt, Hong Zhao, Lauren Averett, Liming Yang, Wyndham H. Wilson, Elaine S. Jaffe, Richard Simon, Richard D. Klausner, John Powell, Patricia L. Duffey, Dan L. Longo, Timothy C. Greiner, Dennis D. Weisenburger, Warren G. Sanger, Bhavana J. Dave, James C. Lynch, Julie Vose, James O. Armitage, Emilio Montserrat, Armando López-Guillermo, Thomas M. Grogan, Thomas P. Miller, Michel LeBlanc, German Ott, Stein Kvaloy, Jan Delabie, Harald Holte, Peter Krajci, Trond Stokke, Louis M. Staudt, The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma The New England Journal of Medicine. ,vol. 346, pp. 1937- 1947 ,(2002) , 10.1056/NEJMOA012914
R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul B. Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yandan Yang, Weihong Xu, Arthur L. Shaffer, George Wright, Wenming Xiao, John Powell, Jian-kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend B. Smeland, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, J. R. Cook, Dennis D. Weisenburger, Wing C. Chan, Susan K. Pierce, Louis M. Staudt, Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma Nature. ,vol. 463, pp. 88- 92 ,(2010) , 10.1038/NATURE08638
Charles G. Mullighan, Salil Goorha, Ina Radtke, Christopher B. Miller, Elaine Coustan-Smith, James D. Dalton, Kevin Girtman, Susan Mathew, Jing Ma, Stanley B. Pounds, Xiaoping Su, Ching-Hon Pui, Mary V. Relling, William E. Evans, Sheila A. Shurtleff, James R. Downing, Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia Nature. ,vol. 446, pp. 758- 764 ,(2007) , 10.1038/NATURE05690
Michael R. Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd R. Golub, Jeffery L. Kutok, Margaret A. Shipp, Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma Blood. ,vol. 116, pp. 3268- 3277 ,(2010) , 10.1182/BLOOD-2010-05-282780
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz, Laia Bassaganyas, Tycho Baumann, Manel Juan, Mónica López-Guerra, Dolors Colomer, José MC Tubío, Cristina López, Alba Navarro, Cristian Tornador, Marta Aymerich, María Rozman, Jesús M Hernández, Diana A Puente, José MP Freije, Gloria Velasco, Ana Gutiérrez-Fernández, Dolors Costa, Anna Carrió, Sara Guijarro, Anna Enjuanes, Lluís Hernández, Jordi Yagüe, Pilar Nicolás, Carlos M Romeo-Casabona, Heinz Himmelbauer, Ester Castillo, Juliane C Dohm, Silvia de Sanjosé, Miguel A Piris, Enrique De Alava, Jesús San Miguel, Romina Royo, Josep L Gelpí, David Torrents, Modesto Orozco, David G Pisano, Alfonso Valencia, Roderic Guigó, Mónica Bayés, Simon Heath, Marta Gut, Peter Klatt, John Marshall, Keiran Raine, Lucy A Stebbings, P Andrew Futreal, Michael R Stratton, Peter J Campbell, Ivo Gut, Armando López-Guillermo, Xavier Estivill, Emili Montserrat, Carlos López-Otín, Elías Campo, None, Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature. ,vol. 475, pp. 101- 105 ,(2011) , 10.1038/NATURE10113
Ryan T. Phan, Riccardo Dalla-Favera, The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells Nature. ,vol. 432, pp. 635- 639 ,(2004) , 10.1038/NATURE03147