Microbial Factor-Mediated Development in a Host-Bacterial Mutualism
作者： Tanya A Koropatnick , Jacquelyn T Engle , Michael A Apicella , Eric V Stabb , William E Goldman
关键词: Inflammation 、 Vibrio 、 Lipopolysaccharide 、 Euprymna scolopes 、 Tracheal cytotoxin 、 Microbiology 、 Light organ 、 Biology 、 Peptidoglycan 、 Pathogenesis 、 Multidisciplinary
摘要: Tracheal cytotoxin (TCT), a fragment of the bacterial surface molecule peptidoglycan (PGN), is factor responsible for extensive tissue damage characteristic whooping cough and gonorrhea infections. Here, we report that Vibrio fischeri also releases TCT, which acts in synergy with lipopolysaccharide (LPS) to trigger development its mutualistic symbiosis squid Euprymna scolopes. As components PGN LPS have commonly been linked pathogenesis animals, these findings demonstrate host interpretation signal molecules context dependent. Therefore, such differences can lead either inflammation disease or establishment mutually beneficial animal-microbe association.
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