Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis.
作者： Jie Yu , Yuanming Fan , Li Wang , Yanjuan Huang , Jingyi Xia
关键词: Physical examination 、 Ataxia 、 Gut flora 、 Acute cerebellar ataxia 、 Score plot 、 Gut–brain axis 、 Medicine 、 Physiology 、 Brain function 、 Intestinal surgery
摘要: Introduction: Acute cerebellar ataxia (ACA) is the most common form of pediatric ataxia. Changes in gut flora can modulate nervous system, influencing brain function via gut-brain axis (GBA). This study aimed to illustrate relationship between intestinal microbiota and ACA. Method: A total 30 12 children were randomly sampled from history surgery (HOIS) no groups (NHOIS), respectively. In addition, 10 healthy who sought physical examination Children's Hospital Nanjing Medical University recruited as a control group. The stool samples 16S rRNA detected. Results: We observed that many ACA had prior onset sequencing indicated HOIS well-distinguished by principal component analysis. discrepancy NHOIS also displayed analysis score plot. However, differences found groups. results student's t-test consistent with nine different genera identified Five phylum showed significant Conclusion: Altered phyla associated identified. Our findings provide new insight into treating preventing
frontiersin.org
sci-hub.se 参考文章(30)
Paola Maria Cutroneo, Domenico Italiano, Gianluca Trifirò, Gaetano Tortorella, Alessandra Russo, Stefania Isola, Achille Patrizio Caputi, Edoardo Spina, Acute Cerebellar Ataxia Following Meningococcal Group C Conjugate Vaccination Journal of Child Neurology. ,vol. 29, pp. 128- 130 ,(2014) , 10.1177/0883073812469724
John F. Cryan, Timothy G. Dinan, Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour Nature Reviews Neuroscience. ,vol. 13, pp. 701- 712 ,(2012) , 10.1038/NRN3346
Ian F. Pollack, Elad I. Levy, Anthony E. Harris, Bennet I. Omalu, Ronald L. Hamilton, Barton F. Branstetter IV, Sudden Death from Fulminant Acute Cerebellitis Pediatric Neurosurgery. ,vol. 35, pp. 24- 28 ,(2001) , 10.1159/000050381
Takashi Shiihara, Mitsuhiro Kato, Akihiro Konno, Yukitoshi Takahashi, Kiyoshi Hayasaka, Acute cerebellar ataxia and consecutive cerebellitis produced by glutamate receptor δ2 autoantibody Brain & Development. ,vol. 29, pp. 254- 256 ,(2007) , 10.1016/J.BRAINDEV.2006.09.004
Emeran A. Mayer, Gut feelings: the emerging biology of gut–brain communication Nature Reviews Neuroscience. ,vol. 12, pp. 453- 466 ,(2011) , 10.1038/NRN3071
Paul Forsythe, Nobuyuki Sudo, Timothy Dinan, Valerie H. Taylor, John Bienenstock, Mood and gut feelings. Brain Behavior and Immunity. ,vol. 24, pp. 9- 16 ,(2010) , 10.1016/J.BBI.2009.05.058
Stephen M. Collins, Michael Surette, Premysl Bercik, The interplay between the intestinal microbiota and the brain Nature Reviews Microbiology. ,vol. 10, pp. 735- 742 ,(2012) , 10.1038/NRMICRO2876
Hideji Hayakawa, Toshiyuki Katoh, Severe cerebellar atrophy following acute cerebellitis Pediatric Neurology. ,vol. 12, pp. 159- 161 ,(1995) , 10.1016/0887-8994(94)00119-M
Mahesh Kamate, Vivek Chetal, Virupaxi Hattiholi, Fulminant cerebellitis: a fatal, clinically isolated syndrome. Pediatric Neurology. ,vol. 41, pp. 220- 222 ,(2009) , 10.1016/J.PEDIATRNEUROL.2009.03.018
Paul Forsythe, Wolfgang A. Kunze, Voices from within: gut microbes and the CNS. Cellular and Molecular Life Sciences. ,vol. 70, pp. 55- 69 ,(2013) , 10.1007/S00018-012-1028-Z