A General Strategy for Facile Synthesis and In Situ Screening of Self-Assembled Polymer-Peptide Nanomaterials.
作者： Zeng-Ying Qiao , Yao-Xin Lin , Wen-Jia Lai , Chun-Yuan Hou , Yi Wang
关键词: Polymer 、 Nanomaterials 、 Nanotechnology 、 Self-assembly 、 Materials science 、 Nanoparticle 、 Combinatorial chemistry 、 Peptide sequence 、 In vivo 、 In situ 、 Peptide
摘要: A universal strategy for efficient, mild, and purification-free synthesis in situ screening of functional polymer-peptide nanomaterials is described. More than 1000 conjugates (PPCs) with various chemical structures, compositions, therapeutic efficacy are created. According to this strategy, the structure-function relationship PPCs revealed, antitumor efficacies top performing evaluated vivo.
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