Well-Defined Protein/Peptide-Polymer Conjugates by Aqueous Cu-LRP: Synthesis and Controlled Self-Assembly.

摘要: The synthesis of well-defined protein/peptide–polymer conjugates with interesting self-assembly behavior via single electron transfer living radical polymerization in water is described. A range protein/peptides different physical and chemical properties have been modified to macroinitiators optimized conditions ensure successful from soluble, insoluble, dispersed protein/peptide molecules or protein aggregates. This powerful strategy tolerates a functional monomers mediates efficient homo block copolymerization generate hydrophilic polymers controlled molecular weight (MW) narrow MW distribution. polymerizations bovine insulin follow surface-initiated “grafting from” mechanism may involve series disassembly processes. Synthesized insulin-polymer form spheres water, the could be thermal control, carbohydrate–pro...