The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhance their therapeutic potential

摘要: Abstract The development of protein drugs for therapeutic purposes using recombinant DNA technology has generated a great deal interest in methods enhancing their delivery. One method improving the delivery proteins, and thereby increasing index, is covalent conjugation to polymers. This paper discusses polymers which are suitable conjugation, properties polymer-protein conjugates possibilities designing drug systems these conjugates. protein-polymer include dramatic increase bioavailability, decreased immunogenicity, enhanced solubility stability. These altered improve efficacy proteins impart flexibility clinical usage.