Markers of endothelial dysfunction and inflammation predict progression of diabetic nephropathy in African Americans with type 1 diabetes.

摘要: African Americans with early-onset type 1 diabetes mellitus are at a high risk for severe diabetic nephropathy and end-stage renal disease. In order to determine whether baseline plasma levels of inflammatory markers predict incidence overt proteinuria or failure in mellitus, we re-examined data 356 participants our observational follow-up study 725 New Jersey diabetes. At 6-year follow-up, detailed structured clinical interview was conducted document medical history including kidney dialysis transplant, other complications, renal-specific mortality. Plasma 28 biomarkers were measured using multiplex bead analysis system. After adjusting age, glycohemoglobin, confounders, the soluble intercellular adhesion molecule-1 (sICAM-1) upper two quartiles were, respectively, associated three- fivefold increase progression from no albuminuria microalbuminuria proteinuria. Baseline chemokine eotaxin quartile significantly sevenfold incident failure. These associations independent traditional factors nephropathy. Thus, Americans, sICAM-1 predicted eotaxin-predicted