Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria.
作者： Jingfang Liu , Zhenjun Zhao , Mark D. P. Willcox , Banglao Xu , Bingyin Shi
DOI: 10.1080/15321819.2010.524860
关键词:
摘要: Renal damage of diabetic patients is linked to chronic low-grade inflammation. The aim this study was analyze urinary concentrations 27 cytokines in type 2 with normo- and microalbuminuria by multiplex bead immunoassay. Urinary levels IL-8, IP-10, MCP-1, G-CSF, EOTAXIN, RANTES, TNF-α microalbuminuric were significantly increased compared those normoalbuminuric (p < 0.05) or controls (p < 0.05). GM-CSF, MIP-1α, MIP-1β more elevated than (both p < 0.05). IP-10 MCP-1 correlated albumin excretion rate (r = 0.668 0.544, both p < 0.01), estimated glomerular filtration (r = −0.454 −0.418, RANTES HbA1c (r = 0.457, 0.466, 0.678, 0.567, 0.542, respectively, p ≤ 0.01). These results indicate that cytokine determination might be useful for the early diagnosis managem...
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