Inter-observer variability in the measurement of diffuse intrinsic pontine gliomas

摘要: Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem tumor with a poor prognosis. Patients commonly enter investigational trials, many of which use radiographic response as endpoint for assessing drug efficacy. However, DIPGs are difficult to measure on magnetic resonance imaging (MRI). In this study, we characterized the reproducibility these performed measurements. Each four readers measured 50 MRI scans from DIPG patients and inter-observer variability was estimated descriptive statistics. Results confirmed that there wide in measurements between all image types. Measurements FLAIR were most consistent. For clinical measurement should be by single reader while comparing prior images side-by-side. Endpoints trials determining efficacy population also include more objective measures, such survival, additional endpoints need investigated.