Sex-Dependent Cognitive Performance in Baboon Offspring Following Maternal Caloric Restriction in Pregnancy and Lactation
作者： Jesse S. Rodriguez , Thad Q. Bartlett , Kathryn E. Keenan , Peter W. Nathanielsz , Mark J. Nijland
关键词: Sex characteristics 、 Baboon 、 Endocrinology 、 Offspring 、 Effects of sleep deprivation on cognitive performance 、 Impulsivity 、 Internal medicine 、 Gestation 、 Medicine 、 Lactation 、 Pregnancy
摘要: In humans a suboptimal diet during development has negative outcomes in offspring. We investigated the behavioral baboons born to mothers undergoing moderate maternal nutrient restriction (MNR). Maternal (n = 7) were fed 70% of food eaten by controls (CTR, n 12) ad libitum throughout gestation and lactation. At 3.3 ± 0.2 (mean standard error mean [SEM]) years age offspring (controls: female [FC, 8], male [MC, 4]; restricted: [FR, 3] [MR, 4]) administered progressive ratio, simple discrimination, intra-/extra-dimension set shift delayed matching sample tasks assess motivation, learning, attention, working memory, respectively. A treatment effect was observed MNR who demonstrated less motivation impaired memory. Nutrient-restricted showed improved while MR learning attentional shifting increased impulsivity. summary, 30% caloric intake long lasting neurobehavioral adolescent baboon
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