Immune responses to insulin in patients with insulin-dependent diabetes mellitus.
作者： T. Scheinin , L. Groop , S. Koskimies And , S. Kontiainen
DOI: 10.3109/08916938909034360
关键词: Immunology 、 In patient 、 Antibody 、 Immune system 、 Diabetes mellitus 、 Internal medicine 、 Insulin 、 Insulin Antibody 、 Medicine 、 Endocrinology 、 Peripheral blood mononuclear cell 、 Human leukocyte antigen
摘要: To examine the effect of major histocompatibility locus (HLA) and duration insulin-dependent diabetes (IDDM) on immune responses to insulin we assayed induced proliferation blood mononuclear cells measured antibodies in 66 patients with newly diagnosed 56 longstanding IDDM matched for age at onset (≤ 15 yrs). In up two thirds responded insulins by proliferation, were found long duration. Insulin or not associated any particular HLA antigen. The frequency HLA-DR3 diagosed was increased unlike addition, HLA-B8 nearly twice as often IDDM. Thus, recent within last three years more frequently resp...
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