Clinical and immunologic studies of HLA-DR typed insulin-dependent diabetics--a mini-review.

摘要: There is strong association between insulin-dependent (type I) diabetes and the HLA DR3 and/or DR4 factors. Also, evidence has been accumulated that an immune response gene associated to region may be a denominator for development of endocrine autoimmunity. It particularly late onset type I belongs so-called "primary" autoimmune variety also shows increased tendency other disorders. DR 3 4 mechanisms seem influence clinical immunologic findings in diabetes. Basically, this concept supported by on seasonal variations manifestation, viral antibodies, anti-insulin antibody formation, natural course endogenous insulin secretion relation haptotypes . are, however, conflicting data concerning islet cell circulating complexes, incidence diabetic microangiopathy HLA-system. Many these explained basis heterogeneity. But does not necessarily point etiological genetic heterogeneity