Pd(II)-catalyzed aerobic oxidative intramolecular hydroamination and C–H functionalization of N-alkynyl anilines for the synthesis of indole derivatives
作者： Long Ren , Zhuangzhi Shi , Ning Jiao
DOI: 10.1016/J.TET.2013.01.031
关键词: Intramolecular force 、 Hydroamination 、 Aryl 、 Chemistry 、 Indole test 、 Surface modification 、 Medicinal chemistry 、 Molecular oxygen 、 Catalysis 、 Oxidative phosphorylation
摘要: A Pd(II)-catalyzed aerobic oxidative approach to 2,3-dihydro-1H-pyrrolo[1,2-a]indoles from simple N-alkynyl anilines through tandem intramolecular hydroamination and aryl C–H activation process has been developed. Molecular oxygen was used as the sole oxidant recycle Pd-catalysis. This protocol is attractive due available starting materials valuable products.
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