New light on phosphate transfer from triesters
作者： Anthony J. Kirby , José R. Mora , Faruk Nome
DOI: 10.1016/J.BBAPAP.2012.04.010
关键词: Transfer (group theory) 、 Computational chemistry 、 Density functional theory 、 Organic chemistry 、 Phosphate 、 Context (language use) 、 Leaving group 、 Reactivity (chemistry) 、 Taft equation 、 Chemistry 、 Nucleophile
摘要: Abstract The reactivity of triesters is discussed in the general context phosphate transfer, as usually studied for reactions mono- and diesters. Systematic work has typically concentrated on Linear Free Energy Relationships measuring dependence nucleophile leaving group, but new results indicate that it can depend equally strongly two non-leaving (sometimes known spectator) groups. This conclusion supported by first from theoretical calculations: which also predict a two-step mechanism be favored over concerted S N 2(P) even involving groups good p-nitrophenolate. article part Special Issue entitled: Chemistry phosphatases, diesterases triesterases.
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