Discoidin domain receptors: structural relations and functional implications

摘要: Multicellular life relies on the presence of extracellular matrix to provide scaffolding for cells and tissue compartments. To communication between tissues, a multitude cell surface receptors are triggered by soluble ligands components matrix. A large family these transmit signals through use an intrinsic tyrosine kinase function. The subgroup discoidin domain (DDRs) is distinguished from other members receptor homology repeat in their domains that also found variety transmembrane secreted proteins. Sequence comparisons show non-mammalian orthologs DDRs exist: three closely related genes Caenorhabditis one sponge Geodia cydonium. Recently, various types collagen have been identified as two mammalian kinases, DDR1 DDR2. binding results de...