Minichromosomal variable surface glycoprotein genes and molecular karyotypes of Trypanosoma (Nannomonas) congolense
作者： Phelix A.O. Majiwa , John R. Young , Raymond Hamers , Gaston Matthyssens
DOI: 10.1016/0378-1119(86)90097-1
关键词: Antigenic variation 、 Gene 、 Trypanosoma 、 Glycoprotein 、 Molecular biology 、 Chromosome 、 Biology 、 Gel electrophoresis 、 Variable surface glycoprotein 、 Gene rearrangement 、 Genetics 、 General Medicine
摘要: Employing orthogonal-field-alternation gel electrophoresis (OFAGE), we have separated chromosome-sized DNA molecules from Trypanosoma (Nannomonas) congolense clones, the clones being derived several distinct antigenic repertoires. Trypanosome that belong to a specific repertoire appear chromosome pattern characteristic of particular repertoire. Hybridization chromosomes with cloned fragments encoding variable surface glycoproteins revealed presence two different T.(N.) glycoprotein genes on mini-chromosomes (mc) and modes by which these may be activated: one duplicative other non-duplicative activation.
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