Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.
作者： S J Wallace , J A Smith
关键词: Phenobarbital 、 Anesthesia 、 Febrile convulsions 、 Valproic Acid 、 Medicine 、 Convulsion 、 General Medicine
摘要: A total of 184 six-month periods were analysed during which feverish illnesses occurred in children aged 6-42 months with a history febrile convulsion. Fits 34 out 100 such when no treatment was being given, six 45 the serum phenobarbitone concentration 69.0 mumol/l (1.6 mg/100 ml) or more, and five 39 plasma valproic acid 416.4 (6.0 more. Thus adequate dosage both significantly better than preventing convulsions (p less 0.02). The two drugs comparable efficacy. It is concluded that improved compliance acid, relatively free from side effects, might be an effective prophylactic agent against convulsions.
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