Synthesis of Mono‐, Di‐, and Tri‐3,4‐dimethoxycinnamoyl‐1,5‐γ‐quinides
作者： Valentina Sinisi , Katarína Boronová , Silvia Colomban , Luciano Navarini , Federico Berti
关键词: Acylation 、 Direct coupling 、 Quinic acid 、 Medicinal chemistry 、 Organic chemistry 、 Chloride 、 Chemistry
摘要: Tri-3,4-dimethoxycinnamoyl-1,5-γ-quinide was synthesized and fully characterized by a direct synthesis from quinic acid large excess of 3,4-dimethoxycinnamoyl chloride. Mono- di-3,4-dimethoxycinnamoyl-1,5-γ-quinides were also obtained the coupling 1,5-γ-quinide chloride in different molar ratios. Moreover, hypothetical mechanism lactonization is proposed.
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