Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence.

摘要: Methadone and QT Prolongation. Background: is associated with QTc prolongation sudden death in susceptible patients. We sought to investigate whether there a gender-based difference susceptibility methadone-associated heroin-dependent patients receiving low-dose treatment regimen. Methods: A cross-sectional assessment of dose gender effects was performed 283 (229 males, 54 females) who received 12-lead ECG for measurement 59 days (interquartile range: 36–288 days) after methadone treatment. To determine the over time, subset 150 participants (126 men, 24 women) underwent before 37 32–44 were selected. Results: In study, significant dose-dependent interaction between (r = 0.201, P 0.0007) observed individuals median 40 mg/day 30–60 mg/day). The methadone-QTc correlation males 0.210, 0.0014) but not females 0.164, 0.2363). longitudinal methadone's 6-month period showed that 60.7% experienced an increase compared baseline data. adjusted significantly increased from 418.5 426.9 milliseconds (P < 0.0001), insignificant change (437.7 vs 441.1 milliseconds, 0.468). Conclusions: Low-dose therapy shows lengthening within 6 months initiation. Men are more than women prolongation. (J Cardiovasc Electrophysiol, Vol. 23, pp. 527-533, May 2012)