作者: George Peoples , Sathibalan Ponniah
DOI:
关键词: Oncology 、 Internal medicine 、 Breast cancer 、 Booster dose 、 T cell immunity 、 Neu oncogene 、 Breast cancer recurrence 、 Medicine 、 Adjuvant 、 Cytotoxic T cell 、 Immunology 、 Immunity
摘要: Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response peptide of the HER/neu oncogene, GP2, with effect inducing maintaining or therapeutic immunity against breast cancer in patient clinical remission, including patients having low intermediate levels HER2/neu expression. The comprise administering an effective amount vaccine composition comprising pharmaceutically acceptable carrier, adjuvant such as GM-CSF, GP2 peptide. may further periodic booster dose needed due declining GP2-specific T cell immunity. Also provided compositions for use methods.