Isolated antigenic oncogene peptide fragments and uses

摘要: An isolated antigenic peptide fragment that is an oncogene protein disclosed. The of the invention a either 9 or 10 amino acid residues in length includes at least leucine residue C- terminus (i.e., position 10). capable binding HLA-A2 cleft and stimulating proliferation one tumor-specific cytotoxic T-lymphocyte. Preferred peptides further include isoleucine 2 valine 6. most preferred can stimulate T-lymphocytes obtainable from peripheral blood lymphocytes, ovarian tumors, breast gastric non-small cell lung pancreatic colon gliomas, bladder endometrial tumors neuroblastomas. mutant defined by SEQ ID NO.:2 its functional equivalents. Isolated recognizing invention, particularly HER2/neu are These lymphocytes especially useful for killing other cells which present on their surfaces invention. In particular, tumor cells, non-small-cell cells. A method described. This obtaining tissue contacting with under conditions sufficient to proliferate. Therapeutically effective compositions containing also