Response to Commentary on "The influence of lung airways branching structure and diffusion time on measurements and models of short-range 3He gas MR diffusion".

摘要: Abstract Our extensive investigation of the cylinder model theory through numerical modelling and purpose-designed experiments has demonstrated that it does produce inaccurate estimates airway dimensions at all diffusion times currently used. This is due to a variety effects: incomplete treatment non-Gaussian effects, finite size, branching geometry, background susceptibility gradients time dependence 3 He MR behaviour in acinar airways. The good starting point for development lung morphometry technique from but its limitations need be understood documented interest reliable clinical interpretation.