Cytoreductive surgery and adjuvant immunotherapy: a new management paradigm for metastatic melanoma.

作者: D. L. Morton , D. W. Ollila , E. C. Hsueh , R. Essner , R. K. Gupta

DOI: 10.3322/CANJCLIN.49.2.101

关键词: Metastatic melanomaOncologyDiseaseTreatment planAdjuvantCytoreductive surgeryInternal medicineTumor burdenImmunotherapyImmune systemMedicine

摘要: Although patients with metastatic disease are usually not offered surgery as part of their comprehensive treatment plan, the authors suggest that surgical reduction tumor burden may enhance host immune response and create a favorable setting for use active specific immunotherapy.

参考文章(68)
Folkman J, The role of angiogenesis in tumor growth. Seminars in Cancer Biology. ,vol. 3, pp. 65- 71 ,(1992)
Skipper He, Laboratory models: some historical perspective. Cancer treatment reports. ,vol. 70, pp. 3- 7 ,(1986)
Morton Dl, Barth A, Wanek La, Prognostic factors in 1,521 melanoma patients with distant metastases. Journal of The American College of Surgeons. ,vol. 181, pp. 193- 201 ,(1995)
Adson Ma, Ilstrup Dm, Fortner Jg, Daly Jm, Hughes Ks, Maclean Bj, Simon R, Foster Jh, Fitzherbert D, Songhorabodi S, Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery. ,vol. 100, pp. 278- 284 ,(1986)
Hsueh Ec, Morton Dl, Leopoldo Zc, Yee R, Qi K, Gupta Rk, TA90 immune complex predicts survival following surgery and adjuvant vaccine immunotherapy for stage IV melanoma. The cancer journal from Scientific American. ,vol. 3, pp. 364- 370 ,(1997)
J.-C. Bystryn, Clinical activity of a polyvalent melanoma antigen vaccine. Recent results in cancer research. ,vol. 139, pp. 337- 348 ,(1995) , 10.1007/978-3-642-78771-3_26
David H. Harpole, Cheryl M. Johnson, Walter G. Wolfe, Stephen L. George, Hilliard F. Seigler, ANALYSIS OF 945 CASES OF PULMONARY METASTATIC MELANOMA The Journal of Thoracic and Cardiovascular Surgery. ,vol. 103, pp. 743- 750 ,(1992) , 10.1016/S0022-5223(19)34957-8
M Sivanandham, B Mukherji, N G Chakraborty, M T Ergin, K E Hellstrom, D R Twardzik, Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response. Journal of Immunology. ,vol. 145, pp. 2359- 2364 ,(1990)
A. L. Nashed, M. T. Ergin, Amala Guha, Bijai Mukherji, Regulation of cellular immune response against autologous human melanoma. II. Mechanism of induction and specificity of suppression. Journal of Immunology. ,vol. 136, pp. 1893- 1898 ,(1986)