Differential cortical neurotrophin and cytogenetic adaptation after voluntary exercise in normal and amnestic rats

摘要: Voluntary exercise (VEx) has profound effects on neural and behavioral plasticity, including recovery of CNS trauma disease. However, the unique regional cortical adaption to VEx not been elucidated. In a series experiments, we first examined whether would restore retain neurotrophin levels in several regions (frontal cortex [FC], retrosplenial [RSC], occipital [OC]) an animal model (pyrithiamine-induced thiamine deficiency [PTD]) amnestic disorder Wernicke-Korsakoff syndrome. addition, assessed time-dependent effect rescue performance spontaneous alternation task. Following 2-weeks or stationary housing conditions (Stat), rats were behaviorally tested brains harvested either day after (24-h) additional 2-week period (2-wk). both control pair-fed (PF) PTD rats, all (brain-derived neurotrophic factor [BDNF], nerve growth [NGF], vascular endothelial factor) increased at 24-h FC RSC, but OC. Two-weeks following VEx, BDNF remained elevated whereas NGF only FC. Interestingly, recovered cognitive when there was 2-wk adaptation VEx. Given this temporal profile, Experiment 2 cytogenetic responses three healthy survival progenitor cells oligodendrocyte precursor (OLPs) Furthermore, had selective recovering OLPs rats. These data reveal therapeutic potential plasticity brain, that is one most responsive