BDNF regains function in hippocampal long-term potentiation deficits caused by diencephalic damage
作者： Lindsey C. Vedder , Lisa M. Savage
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摘要: Thiamine deficiency (TD), commonly associated with chronic alcoholism, leads to diencephalic damage, hippocampal dysfunction, and spatial learning memory deficits. We show a decrease in the magnitude of long-term potentiation (LTP) paired-pulse facilitation (PPF) at CA3-CA1 synapses, independent sex, following damage induced by TD rats. Thus, despite lack extensive cell loss, brain down-regulates plastic processes within hippocampus, likely contributing impaired hippocampal-dependent behaviors. However, both measures plasticity (LTP, PPF) were restored brain-derived neurotrophic factor (BDNF), revealing an avenue for neural behavioral recovery damage.
sci-hub.se 参考文章(55)
Endel Tulving, Multiple memory systems and consciousness. Human neurobiology. ,vol. 6, pp. 67- 80 ,(1987)
Caroline C. Smith, Lindsey A. Smith, Teruko M. Bredemann, Lori L. McMahon, 17β estradiol recruits GluN2B-containing NMDARs and ERK during induction of long-term potentiation at temporoammonic-CA1 synapses Hippocampus. ,vol. 26, pp. 110- 117 ,(2016) , 10.1002/HIPO.22495
PS Katz, MD Kirk, CK Govind, Facilitation and depression at different branches of the same motor axon: evidence for presynaptic differences in release The Journal of Neuroscience. ,vol. 13, pp. 3075- 3089 ,(1993) , 10.1523/JNEUROSCI.13-07-03075.1993
Rosa Draisci, Mauro Ceccanti, Maria Luisa Attilia, Rosanna Mancinelli, Mario Vitali, Oreste Senofonte, Rosanna Maria Fidente, Eleonora Barlocci, Maria Ciprotti, Marco Fiore, Blood thiamine, zinc, selenium, lead and oxidative stress in a population of male and female alcoholics: clinical evidence and gender differences Annali dell'Istituto Superiore di Sanità. ,vol. 49, pp. 65- 72 ,(2013) , 10.4415/ANN_13_01_11
Eric G. Mohler, Phillip M. Baker, Kimberly S. Gannon, Simon S. Jones, Sharon Shacham, John A. Sweeney, Michael E. Ragozzino, The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats Psychopharmacology. ,vol. 220, pp. 687- 696 ,(2012) , 10.1007/S00213-011-2518-7
C. C. Smith, Estrogen-Induced Increase in the Magnitude of Long-Term Potentiation Occurs Only When the Ratio of NMDA Transmission to AMPA Transmission Is Increased The Journal of Neuroscience. ,vol. 25, pp. 7780- 7791 ,(2005) , 10.1523/JNEUROSCI.0762-05.2005
J.M. Hall, R.P. Vetreno, L.M. Savage, Differential cortical neurotrophin and cytogenetic adaptation after voluntary exercise in normal and amnestic rats Neuroscience. ,vol. 258, pp. 131- 146 ,(2014) , 10.1016/J.NEUROSCIENCE.2013.10.075
Marta Zagrebelsky, Martin Korte, Form follows function: BDNF and its involvement in sculpting the function and structure of synapses. Neuropharmacology. ,vol. 76, pp. 628- 638 ,(2014) , 10.1016/J.NEUROPHARM.2013.05.029
Lindsey C. Vedder, Teruko M. Bredemann, Lori L. McMahon, Estradiol replacement extends the window of opportunity for hippocampal function. Neurobiology of Aging. ,vol. 35, pp. 2183- 2192 ,(2014) , 10.1016/J.NEUROBIOLAGING.2014.04.004
J.R. Dumont, E. Amin, G.L. Poirier, M.M. Albasser, J.P. Aggleton, Anterior thalamic nuclei lesions in rats disrupt markers of neural plasticity in distal limbic brain regions. Neuroscience. ,vol. 224, pp. 81- 101 ,(2012) , 10.1016/J.NEUROSCIENCE.2012.08.027