A new strategy for fabrication of bone scaffolds using electrospun nano-HAp/PHB fibers and protein hydrogels

摘要: Abstract Electrospinning is an effective technology for fabrication of ultrafine fibers suitable a tissue engineering scaffold. A limiting factor electrospun scaffolds however their tightly packed network providing only superficial porous structure. Alternatively, hydrogels can be used to create with well-interconnected structure; but these materials provide poor mechanical stability and very low bioactivity, failing three-dimensional constructs bone engineering. In this study, we therefore developed novel hybrid scaffold system in which mat based on biodegradable polyhydroxybutyrate (PHB) hydroxyapatite (HAp) was combined protein-based hydrogel single tri-layered the resulting construct, while layers environment cell encapsulation, incorporated act as strong backbone increasing properties According results, construct were much higher than traditional hydrogels. Moreover, cells inside highly viable, infiltrated into center after 14 days encapsulation. Given high strength ability encapsulate cells, new cell-laden expected enhance regeneration vivo.