The Biodegradability of Scaffolds Reinforced by Fibers or Tubes for Tissue Repair

摘要: The present chapter gives an overview of the fabrication, biocompatibility and biodegradability flexible scaffold materials reinforced with stiffer nanofiber or nanotube inclusions. need for such filler nanomaterials results from necessity to increase elastic modulus fracture toughness biopolymer materials, as gelatin, chitosan, well synthetic biodegradable polymers, polylactic acid polycaprolactone, that are be used in large bone defect regeneration. For biomedical applications it must possible material support forces exerted by skeletal network, until new tissue is regenerated. Hence, mechanical properties not altered much during initial intermediate degradation stages at which formation occurs. Furthermore, occur slowly only so sufficient formed, but degraded products can levels tolerated cells without inducing cytotoxicity. most widely examined fillers reinforcing strength hydroxyapatite (HA) nanotubes, HA a natural mineral found bone, while other promising candidates include silk, boron nitride, magnesium alloy nanowires. Another common combination use polymer fiber reinforcements, within soft matrix, meshes embedded hydrogels, form laminates then stacked. particular systems covered this are: (i) gelatin nanofibers, (ii) chitosan nitride (iii) polylactide–polycaprolactone (iv) nano-hydroxyapatite/collagen/PLLA chitin fibers, (v) poly-lactic nanowires, (vi) polycaprolactone poly-L-lactic (vii) polyactic silk (viii) poly(lactide-co-ethylene oxide fumarate) gel mesh (ix) protein hydrogels nano-HAp/PHB network. Standard testing (such tension bending) has shown all these types nanocomposite scaffolds exhibit preferred reducing biocompatibility. Upon giving brief microstructure, strength, each scaffold, their will elaborated on focus chapter.