Benzolactam compounds as protein kinase inhibitors
作者： Charlotte Mary Griffiths-Jones , Alison Jo-Anne Woolford , John Paul Watts , James Edward Harvey Day , Michael Liam Cooke
DOI:
关键词: Protein kinase A 、 Halogen 、 Salt (chemistry) 、 Hydrocarbon 、 Hydrogen 、 Fluorine 、 Stereochemistry 、 Alkyl 、 Tautomer 、 Chemistry
摘要: The invention provides a compound of formula (0): or pharmaceutically acceptable salt, N-oxide tautomer thereof; wherein: n is 1 2; X CH N; Y selected from and C—F; Z C—R z R from: -(Alk ) t -Cyc ; wherein 0 1; Optionally substituted C 1-6 acyclic hydrocarbon groups 2 hydrogen; halogen; 1-3 optionally with one more fluorine atoms; 3 hydrogen group L -R 7 4 methoxy; alkyl; 4a alkyl group; , Alk Cyc are defined herein; provided that the other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one salts tautomers thereof. compounds inhibitors ERK1/2 kinases will be useful in treatment ERK1/2-mediated conditions. therefore therapy, particular cancer.
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