Fumiquinazolines A–G, novel metabolites of a fungus separated from a Pseudolabrus marine fish

作者: Chika Takahashi , Tomochika Matsushita , Mitsunobu Doi , Katsuhiko Minoura , Tetsuro Shingu

DOI: 10.1039/P19950002345

关键词: Strain (chemistry)ChemistryPseudolabrus japonicusBiochemistryFungusPseudolabrusMarine fishCytotoxicityAspergillus fumigatus

摘要: Seven new fumiquinazolines (FQs) A–G have been isolated from a strain of Aspergillus fumigatus originally separated the marine fish Pseudolabrus japonicus, and their stereostructures conformations established on basis spectral X-ray analyses some chemical transformations. All compounds exhibited moderate cytotoxicity against cultured P388 cells.

参考文章(18)
MIKIO YAMAZAKI, HARUHIRO FUJIMOTO, EMI OKUYAMA, Structure of tryptoquivaline C (FTC) and D (FTD). Novel fungal metabolites from Aspergillus fumigatus. Chemical & Pharmaceutical Bulletin. ,vol. 25, pp. 2554- 2560 ,(1977) , 10.1248/CPB.25.2554
MIKIO YAMAZAKI, HARUHIRO FUJIMOTO, EMI OKUYAMA, Structure Determination of Six Fungal Metabolites, Tryptoquivaline E, F, G, H, I and J from Aspergillus fumigatus Chemical & Pharmaceutical Bulletin. ,vol. 26, pp. 111- 117 ,(1978) , 10.1248/CPB.26.111
Atsushi Numata, Chika Takahashi, Yoshinori Ito, Tamie Takada, Kenzo Kawai, Yoshihide Usami, Eiko Matsumura, Misako Imachi, Tadayoshi Ito, Toru Hasegawa, Communesins, cytotoxic metabolites of a fungus isolated from a marine alga Tetrahedron Letters. ,vol. 34, pp. 2355- 2358 ,(1993) , 10.1016/S0040-4039(00)77612-X
Chika Takahashi, Atsushi Numata, Yoshinori Ito, Eiko Matsumura, Hiromasa Araki, Hideo Iwaki, Katsuhiko Kushida, Leptosins, antitumour metabolites of a fungus isolated from a marine alga Journal of the Chemical Society, Perkin Transactions 1. pp. 1859- 1864 ,(1994) , 10.1039/P19940001859
Martin Karplus, Contact Electron‐Spin Coupling of Nuclear Magnetic Moments The Journal of Chemical Physics. ,vol. 30, pp. 11- 15 ,(1959) , 10.1063/1.1729860
Chika Takahashi, Katsuhiko Minoura, Takeshi Yamada, Atsushi Numata, Katsuhiko Kushida, Tetsuro Shingu, Sanji Hagishita, Hiroshi Nakai, Tomohiro Sato, Hiroshi Harada, Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis Tetrahedron. ,vol. 51, pp. 3483- 3498 ,(1995) , 10.1016/0040-4020(95)00102-E
Atsushi Numata, Chika Takahashi, Tomochika Matsushita, Tamie Miyamoto, Kenzo Kawai, Yoshihide Usami, Eiko Matsumura, Masatoshi Inoue, Hirofumi Ohishi, Tetsuro Shingu, Fumiquinazolines, novel metabolites of a fungus isolated from a saltfish Tetrahedron Letters. ,vol. 33, pp. 1621- 1624 ,(1992) , 10.1016/S0040-4039(00)91690-3
Mari Yotsu, Tomoko Yamazaki, Yuko Meguro, Amane Endo, Michio Murata, Hideo Naoki, Takeshi Yasumoto, Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. Toxicon. ,vol. 25, pp. 225- 228 ,(1987) , 10.1016/0041-0101(87)90245-5
Chika Takahashi, Tamie Takada, Takeshi Yamada, Katsuhiko Minoura, Kenshiro Uchida, Eiko Matsumura, Atsushi Numata, Halichomycin, a new class of potent cytotoxic macrolide produced by an actinomycete from a marine fish Tetrahedron Letters. ,vol. 35, pp. 5013- 5014 ,(1994) , 10.1016/S0040-4039(00)73307-7
Atsushi NUMATA, Peiming YANG, Chika TAKAHASHI, Ryoko FUJIKI, Michiko NABAE, Eiichi FUJITA, Cytotoxic triterpenes from a Chinese medicine, Goreishi Chemical & Pharmaceutical Bulletin. ,vol. 37, pp. 648- 651 ,(1989) , 10.1248/CPB.37.648