The monoamine oxidase catalyzed degradation of phenelzine-1-14C, an irreversible inhibitor of monoamine oxidase—I
作者： B.V. Clineschmidt , A. Horita
DOI: 10.1016/0006-2952(69)90104-X
关键词: Pargyline 、 Endocrinology 、 Internal medicine 、 Monoamine oxidase 、 Metabolite 、 Excretion 、 Pharmacology 、 Tranylcypromine 、 Phenelzine 、 Phenylacetic acid 、 Metabolism 、 Chemistry
摘要: Abstract Rats receiving approx. 2.5 mg kg of phenelzine-1-14C by the intraperitoneal route were placed in metabolism cages and their urine collected for 24 hr. Phenylacetic-1-14C acid was recovered as a major metabolite. Pretreatment animals with tranylcypromine (10 ) or pargyline (100 prior to injection radioactive phenelzine markedly reduced urinary excretion phenylacetic-1-14C other unidentified metabolites appeared increase. Inhibition monoamine oxidase (MAO) had no effect on an equimolar dose administered same route. Therefore, pretreatment rats appears have decreased bioconversion injected phenylacetic acid. These results provide further evidence that phenelzine, addition being irreversible inhibitor, is also substrate MAO intact animal.
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sci-hub.se 参考文章(16)
E. Albert Zeller, James Barsky, Elaine R. Berman, Amine oxidases. XI. Inhibition of monoamine oxidase by 1-isonicotinyl-2-isopropylhydrazine. Journal of Biological Chemistry. ,vol. 214, pp. 267- 274 ,(1955) , 10.1016/S0021-9258(18)70965-4
A. N. Davison, The mechanism of the irreversible inhibition of rat liver monoamine oxidase by iproniazid (Marsilid) Biochemical Journal. ,vol. 67, pp. 316- 322 ,(1957) , 10.1042/BJ0670316
Morton A. Schwartz, THE METABOLISM OF ISOCARBOXAZID (MARPLAN) IN THE RAT Journal of Pharmacology and Experimental Therapeutics. ,vol. 130, pp. 157- 165 ,(1960)
Eugene C. Weinbach, A procedure for isolating stable mitochondria from rat liver and kidney. Analytical Biochemistry. ,vol. 2, pp. 335- 343 ,(1961) , 10.1016/0003-2697(61)90006-9
E. A. Zeller, L. A. Blanksma, W. P. Burkard, W. L. Pacha, J. C. Lazanas, IN VITRO AND IN VIVO INHIBITION OF AMINE OXIDASES Annals of the New York Academy of Sciences. ,vol. 80, pp. 583- 589 ,(2006) , 10.1111/J.1749-6632.1959.TB49236.X
Max Chessin, Bernard Dubnick, Gerald Leeson, Charles C. Scott, BIOCHEMICAL AND PHARMACOLOGICAL STUDIES OF β-PHENYLETHYLHYDRAZINE AND SELECTED RELATED COMPOUNDS Annals of the New York Academy of Sciences. ,vol. 80, pp. 597- 608 ,(2006) , 10.1111/J.1749-6632.1959.TB49238.X
P.A. Shore, V.H. Cohn, Comparative effects of monoamine oxidase inhibitors on monoamine oxidase and diamine oxidase. Biochemical Pharmacology. ,vol. 5, pp. 91- 95 ,(1960) , 10.1016/0006-2952(60)90012-5
E. A. Zeller, Studies on the active center of monoamine oxidase. Cellular and Molecular Life Sciences. ,vol. 16, pp. 399- 402 ,(1960) , 10.1007/BF02178830
CLINESCHMIDT, AKIRA HORITA, Auto-potentiation and potentiation by inhibition of monoamine oxidase of the sympathomimetic action of phenelzine and pheniprazine. British journal of pharmacology and chemotherapy. ,vol. 30, pp. 67- 77 ,(1967) , 10.1111/J.1476-5381.1967.TB02113.X
A.L. Green, STUDIES ON THE MECHANISM OF INHIBITION OF MONOAMINE-OXIDASE BY HYDRAZINE DERIVATIVES. Biochemical Pharmacology. ,vol. 13, pp. 249- 261 ,(1964) , 10.1016/0006-2952(64)90143-1