NF-κB as a therapeutic target in chronic lymphocytic leukemia
作者： Monica Lopez-Guerra , Dolors Colomer
DOI: 10.1517/14728221003598930
关键词: IκB kinase 、 Biology 、 Chronic lymphocytic leukemia 、 Immunology 、 Apoptosis 、 Pathogenesis 、 Transcription factor 、 NF-κB
摘要: Importance of the field: NF-κB includes a family transcription factors that play critical role in biology normal lymphocytes and it is aberrantly activated chronic lymphocytic leukemia (CLL) cells. Here, we review constitutive activation CLL pathogenesis its potential as therapeutic target for treatment.Areas covered this review: This highlights different strategies reported to inhibit signaling They include both IκB kinase inhibitors several natural compounds act at steps pathway.What reader will gain: Targeting leads apoptosis cells, corroborating survival clonal expansion these tumoral Moreover, studies confirmed synergistic effect between other antitumoral agents inhibition could overcome microenvironmental protection cells.Take home message: relevant ...
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