The RET Receptor Is Linked to Stress Response Pathways

摘要: RET is a transmembrane receptor required for the development of neuroendocrine and urogenital cell types. Activation has roles in growth, migration, or differentiation, yet little known about gene expression patterns through which these processes are mediated. We have generated lines stably expressing either RET9 RET51 protein isoforms used to investigate RET-mediated by cDNA microarray analyses. As seen many oncogenes, we identified altered genes associated generally with cell–cell cell-substrate interactions up-regulation tumor-specific transcripts. also saw increased transcripts normally neural crest other RET-expressing types, suggesting may lie downstream activation development. The most striking pattern was stress response genes. showed that significantly up-regulated heat shock (HSP) 70 family members, HSPA1A , HSPA1B HSPA1L . Other members several HSP families HSP70-interacting molecules were complexes involved maturation specifically RET, whereas those HSP70 degradation down-regulated unaffected. major mechanism induction transcription factor HSF1. leads HSF1 activation, correlates Together, our data suggest be directly responsible proteins initiation response.