Total IgE levels and asthma prevalence in the US population: Results from the National Health and Nutrition Examination Survey 2005-2006

摘要: Background The inability to measure IgE-based sensitivity all allergens has limited our understanding of what portion asthma is related IgE. Total IgE measurement can potentially overcome this limitation. Objective We sought determine the association between total levels and asthma. Methods National Health Nutrition Examination Survey 2005-2006 examined a representative sample US population 6 years age older. Results median level was 40.8 kU/L (interquartile range, 15.5-114 kU/L). varied with age, sex, race/ethnicity, serum cotinine level, body size, socioeconomic status. prevalence current 8.8%. atopy 42.5%, as defined by 15 specific IgEs. adjusted odds ratio (OR) for 10-fold increase in 2.18 (95% CI, 1.66-2.87). predicted only among atopic subjects (OR, 2.41; 95% 1.62-3.60) not nonatopic 1.11; 0.72-1.71; interaction P = .005). Among subjects, became stronger number positive test results increased. Asthma present at even lowest IgE, regardless Approximately 92% were identified IgEs, but identification more than 99% required 11 Conclusion are associated persons who have least 1 allergen-specific independent uncommon population. complete requires large panel