A pilot study assessing the impact of heat on the transdermal delivery of testosterone.
作者： T Samuel Shomaker , Jie Zhang , Michael A. Ashburn
DOI: 10.1177/00912700122010447
关键词: Crossover study 、 Absorption (skin) 、 Androgen 、 Testosterone (patch) 、 Transdermal 、 Endocrinology 、 Area under the curve 、 Medicine 、 Significant difference 、 Internal medicine 、 Pharmacokinetics
摘要: This study evaluated the effect of locally applied heat on transdermal delivery testosterone. Six healthy adult volunteers were tested three times while receiving a 5 mg androgen patch, same patch with heat-generating and no at all over 12 hours. Statistically significant differences in mean maximum serum testosterone concentration values seen. Heat plus resulted 939 ng/dl versus 635 (patch only) 425 (no patch). (Heat + vs. patch: p < 0.001; = 0.003.) The area under curve plasma time means 4114 ng/dl.h 1985 for patch-only group (p 0.001). use improved absorption decreased to peak concentrations, resulting statistically difference concentrations compared without heat.
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