What happens in the skin? Integrating skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure.

作者: Yuri Dancik , Paul L. Bigliardi , Mei Bigliardi-Qi

DOI: 10.1016/J.REPROTOX.2015.10.001

关键词:

摘要: … toxic internal (systemic or organ) concentrations is crucial for the development of toxicity prediction … increase the skin temperature sufficiently to affect skin penetration through increase …

参考文章(356)
Lars Arendt-Nielsen, Parisa Gazerani, Cutaneous vasomotor reactions in response to controlled heat applied on various body regions of healthy humans: evaluation of time course and application parameters. International journal of physiology, pathophysiology and pharmacology. ,vol. 3, pp. 202- 209 ,(2011)
Maureen H. Feuston, Stacy L. Kerstetter, Edward J. Singer, Myron A. Mehlman, Developmental toxicity of Clarified Slurry Oil applied dermally to rats. Toxicology and Industrial Health. ,vol. 5, pp. 587- 599 ,(1989) , 10.1177/074823378900500313
Nancy A. Monteiro‐Riviere, Alfred O. Inman, Jim E. Riviere, Stephen C. McNeill, Michael L. Francoeur, Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature Pharmaceutical Research. ,vol. 10, pp. 1326- 1331 ,(1993) , 10.1023/A:1018973814456
Yuri Dancik, Michael S. Roberts, Gayathri Krishnan, Camilla Thompson, Cutaneous metabolism and active transport in transdermal drug delivery Informa Healthcare USA. ,vol. 29, pp. 69- 82 ,(2010)
Stephen C. McNeill, Russell O. Potts, Michael L. Francoeur, LOCAL ENHANCED TOPICAL DELIVERY (LETD) OF DRUGS: DOES IT TRULY EXIST Pharmaceutical Research. ,vol. 9, pp. 1422- 1427 ,(1992) , 10.1023/A:1015854728278
Efstathios Nikolaidis, Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicity Reproductive and Developmental Toxicology. pp. 111- 121 ,(2011) , 10.1016/B978-0-12-382032-7.10009-8
Puchun Liu, William I. Higuchi, Wei‐qi Song, Tamie Kurihara‐Bergstrom, William R. Good, Quantitative evaluation of ethanol effects on diffusion and metabolism of beta-estradiol in hairless mouse skin. Pharmaceutical Research. ,vol. 8, pp. 865- 872 ,(1991) , 10.1023/A:1015847311266
Brian Davies, Tim Morris, Physiological Parameters in Laboratory Animals and Humans Pharmaceutical Research. ,vol. 10, pp. 1093- 1095 ,(1993) , 10.1023/A:1018943613122
David A. Barrett, Nicholas Rutter, Stanley S. Davis, An in Vitro Study of Diamorphine Permeation Through Premature Human Neonatal Skin Pharmaceutical Research. ,vol. 10, pp. 583- 587 ,(1993) , 10.1023/A:1018958305002