Genome engineering in human pluripotent stem cells
作者： Udit Parekh , Marianna Yusupova , Prashant Mali
DOI: 10.1016/J.COCHE.2016.12.002
关键词: Biology 、 Bioinformatics 、 Genome engineering 、 Computational biology 、 Induced pluripotent stem cell
摘要: Human pluripotent stem cells (hPSCs) hold great promise for modeling and recapitulation of human biological processes. Coupled with the advent genome engineering tools, specifically CRISPR–Cas9 systems, hPSCs have opened a multitude possibilities in biology creating novel cellular therapies. Here, we review fundamentals both technologies, wide-ranging present future applications hPSCs.
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