TP53 promoter methylation in primary glioblastoma: relationship with TP53 mRNA and protein expression and mutation status.

摘要: Reduced expression of TP53 by promoter methylation has been reported in several neoplasms. It remains unclear whether is associated with reduced transcriptional and protein glioblastoma (GB). The aim our work was to study the impact mutations on mRNA level 42 molecularly characterized primary GB tumors. We also evaluate all molecular alterations overall patient survival. frequency found 21.4%. To best knowledge, this first report showing such high GB. There no relation between (p=0.5722) (p=0.2045). No significant associations were mutation gene (p=0.9076). However, association (p=0.0016). Our data suggest that does not play a role silencing probably regulated other genetic epigenetic mechanisms genes involved pathway.