25 Estrogen as a Promising Multi-Active Agent for the Treatment of Spinal Cord Injury

摘要: Spinal cord injury (SCI) causes neurological deficits leading to devastating functional disabilities. The only clinical treatment available is high dose methylprednisolone, which has limited efficacy. Recent studies have recognized estrogen, a steroid hormone, with multi-active properties in neurodevelopment, cell function, and the prevention of pathophysiology central nervous system diseases. Estrogen efficacy, at doses or physiologic dose, been investigated animal models injury, ischemia stroke, as well culture. Many these investigations provided convincing evidence that estrogen significant beneficial effects. This short review describes results obtained from our laboratory on effect experimental SCI rats. data indicated reduced edema inflammation, acted an antioxidant antiapoptotic agent, modulated intracellular Ca, inhibited calpain caspase activities, promoted angiogenesis, preserved axons myelin, improved motor function following These observations CNS trauma diseases strongly suggest will role patients SCI. List Abbreviations: AD, Alzheimer’s disease; AMPA, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDGF, brain-derived growth factor; CNS, system; EAE, autoimmune encephalomyelitis; ER, receptor; MAG, myelin-associated glycoprotein; MBP, myelin basic protein; MP, methylprednisolone; MS, multiple sclerosis; NGF, nerve NFP, neurofilament proteins; NMDA, N-methyl-D-aspartate; NT-3, neurotrophin-3; PD, Parkinson’s PLP, proteolipid PMN, polymorphonuclear cell; SCI, spinal injury; TBI, traumatic brain TNF, tumor necrosis factor