Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line.
作者： Kazuki Ohta , Yukio Hirata , Taihei Imai , Kazuo Kanno , Toshiaki Emori
DOI: 10.1016/0006-291X(90)90370-3
关键词: Cytokine 、 Northern blot 、 Molecular biology 、 Endothelin 1 、 Thrombin 、 Internal medicine 、 Secretion 、 Biology 、 Epithelium 、 Endothelin receptor 、 Cell culture 、 Endocrinology
摘要: Abstract To elucidate the mechanism by which endothelin-1 (ET-1) is released from renal epithelial cells, we have investigated effects of several compounds on release ET-1-like immuno-reactivity (LI) LLCPK 1 cell line. Thrombin, transforming growth factor-β, cytokines (tumor necrotizing factor-α, interleukin-1β), and phorbol ester stimulated ET-1-LI in a time- dose-dependent manner. The cytokine-induced was not affected indomethacin. Northern blot analysis using cDNA for porcine preproET-1 as probe revealed single major band corresponding to size ET-1 mRNA . These data indicate that gene also expressed cells regulated similar endothelial cells.
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