Fibroblast Response to Lanthanoid Metal Ion Stimulation: Potential Contribution to Fibrotic Tissue Injury
作者： William Jenkins , Patricia Perone , Kyle Walker , Narasimharao Bhagavathula , Muhammad Nadeem Aslam
DOI: 10.1007/S12011-011-9041-X
关键词: Immunology 、 Lanthanoid Series Elements 、 Cell growth 、 Fibroblast 、 Matrix (biology) 、 Fibrosis 、 Keratinocyte 、 Stimulation 、 Chemistry 、 Biophysics 、 Magnesium
摘要: The purpose of this study was to compare each the 14 naturally occurring lanthanoid metal ions for ability stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed individual lanthanoids over concentration range 1–100 μM, increased proliferation observed with agents as compared control cells that already proliferating rapidly a growth factor-enriched culture medium. Dose–response differences among ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor levels also response exposure but type I procollagen production not. A dose–response relationship between induction MMP-1 observed. Non-lanthanoid transition (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, zinc) examined same assays; there little stimulation any these metals. epidermal keratinocytes place fibroblasts, no lanthanoids. Several metals inhibited keratinocyte at higher concentrations (50–100 μM).
springer.com
sci-hub.se 参考文章(60)
Christopher H. Evans, Biochemistry of the Lanthanides ,(1990)
Borna Mehrad, Ellen C Keeley, Marie D Burdick, Robert M Strieter, The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis. Transactions of the American Clinical and Climatological Association. ,vol. 120, pp. 49- 59 ,(2009)
Toshinori Sato, Mineo Hashizume, Yasunobu Hotta, Yoshio Okahata, Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions. Biometals. ,vol. 11, pp. 107- 112 ,(1998) , 10.1023/A:1009273827598
Shawn E. Cowper, Morgan Rabach, Michael Girardi, Clinical and histological findings in nephrogenic systemic fibrosis. European Journal of Radiology. ,vol. 66, pp. 191- 199 ,(2008) , 10.1016/J.EJRAD.2008.01.016
Thomas A. Hope, Robert J. Herfkens, Kwame S. Denianke, Phillip E. LeBoit, Yun-Yi Hung, Eli Weil, Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine. Investigative Radiology. ,vol. 44, pp. 135- 139 ,(2009) , 10.1097/RLI.0B013E31819343BA
Ying Zhang, Li-Juan Fu, Jin-Xia Li, Xiao-Gai Yang, Xiao-Da Yang, Kui Wang, None, Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells. Biometals. ,vol. 22, pp. 511- 519 ,(2009) , 10.1007/S10534-009-9208-5
Gary J. Fisher, Subhash C. Datta, Harvinder S. Talwar, Zeng-Quan Wang, James Varani, Sewon Kang, John J. Voorhees, Molecular basis of sun-induced premature skin ageing and retinoid antagonism Nature. ,vol. 379, pp. 335- 339 ,(1996) , 10.1038/379335A0
Jian Hu, Siwang Yu, Xiaoda Yang, Kui Wang, Zhongming Qian, Lanthanum induces extracellular signal-regulated kinase phosphorylation through different mechanisms in HeLa cells and NIH 3T3 cells. Biometals. ,vol. 19, pp. 13- 18 ,(2006) , 10.1007/S10534-005-3182-3
Narasimharao Bhagavathula, Michael K. Dame, Marissa DaSilva, William Jenkins, Muhammad N. Aslam, Patricia Perone, James Varani, Fibroblast Response to Gadolinium: Role for Platelet-Derived Growth Factor Receptor Investigative Radiology. ,vol. 45, pp. 769- 777 ,(2010) , 10.1097/RLI.0B013E3181E943D2
D. Riccardi, D. Maldonado-Perez, The calcium-sensing receptor as a nutrient sensor. Biochemical Society Transactions. ,vol. 33, pp. 316- 320 ,(2005) , 10.1042/BST0330316