Tissue factor pathway inhibitor (TFPI)
作者： P. M. Sandset
DOI: 10.1007/978-94-011-4722-4_18
关键词: Binding site 、 Chemistry 、 Tissue factor pathway inhibitor 、 Inhibitory postsynaptic potential 、 Biochemistry 、 Heparin 、 Glycoprotein 、 Amino acid 、 Glycosylation 、 Protease
摘要: Tissue factor pathway inhibitor (TFPI) is a plasma glycoprotein which belongs to the Kunitz-type family of protease inhibitors. The mature molecule contains 276 amino acids, and consists an acidic terminal end, three tandem inhibitory domains, highly basic carboxyl potential N-linked glycosylation sites1. high-affinity binding site for heparin located in region end2 low-affinity third Kunitz domain3. TFPI produced endothelial cells4. synthesis constitutive not affected by cytokines5.
springer.com
sci-hub.st 参考文章(55)
WF Novotny, M Palmier, TC Wun, GJ Jr Broze, JP Miletich, Purification and properties of heparin-releasable lipoprotein-associated coagulation inhibitor. Blood. ,vol. 78, pp. 394- 400 ,(1991) , 10.1182/BLOOD.V78.2.394.394
TA Warr, BJ Warn-Cramer, LV Rao, SI Rapaport, Human plasma extrinsic pathway inhibitor activity: I. Standardization of assay and evaluation of physiologic variables. Blood. ,vol. 74, pp. 201- 206 ,(1989) , 10.1182/BLOOD.V74.1.201.201
Y Nemerson, Tissue factor and hemostasis Blood. ,vol. 71, pp. 1- 8 ,(1988) , 10.1182/BLOOD.V71.1.1.BLOODJOURNAL7111
PM Sandset, BJ Warn-Cramer, SL Maki, SI Rapaport, Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. Blood. ,vol. 78, pp. 1496- 1502 ,(1991) , 10.1182/BLOOD.V78.6.1496.1496
R Wesselschmidt, K Likert, T Girard, TC Wun, GJ Jr Broze, Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa Blood. ,vol. 79, pp. 2004- 2010 ,(1992) , 10.1182/BLOOD.V79.8.2004.2004
WF Novotny, TJ Girard, JP Miletich, GJ Jr Broze, Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor Blood. ,vol. 72, pp. 2020- 2025 ,(1988) , 10.1182/BLOOD.V72.6.2020.BLOODJOURNAL7262020
WF Novotny, SG Brown, JP Miletich, DJ Rader, GJ Jr Broze, Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood. ,vol. 78, pp. 387- 393 ,(1991) , 10.1182/BLOOD.V78.2.387.BLOODJOURNAL782387
W F Novotny, T J Girard, J P Miletich, G J Broze, Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma. Journal of Biological Chemistry. ,vol. 264, pp. 18832- 18837 ,(1989) , 10.1016/S0021-9258(18)51542-8
GJ Jr Broze, LA Warren, WF Novotny, DA Higuchi, JJ Girard, JP Miletich, The Lipoprotein-Associated Coagulation Inhibitor That Inhibits the Factor VII-Tissue Factor Complex Also Inhibits Factor Xa: Insight Into Its Possible Mechanism of Action Blood. ,vol. 71, pp. 335- 343 ,(1988) , 10.1182/BLOOD.V71.2.335.335
N S Callander, L V Rao, O Nordfang, P M Sandset, B Warn-Cramer, S I Rapaport, Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa. Journal of Biological Chemistry. ,vol. 267, pp. 876- 882 ,(1992) , 10.1016/S0021-9258(18)48365-2