Radio sensitivity of human prostate cancer and malignant melanoma cell lines
作者： Michael Wollin , T.J. FitzGerald , M.A. Santucci , Mani Menon , C. Longcope
DOI: 10.1016/0167-8140(89)90097-2
关键词: Melanoma 、 Prostate cancer 、 Androgen receptor 、 Pathology 、 Cell survival curve 、 DU145 、 Cancer 、 Radiosensitivity 、 Chemistry 、 Cancer research 、 Androgen
摘要: Abstract The relative radioresponsiveness of human prostate cancer compared to malignant melanoma is well known. effects β-estradiol or testosterone on the X-irradiation survival several cell lines were studied, including: carcinoma PC3 and DU145 A375 A875. Lines DU 145 demonstrated 55–61 fmol per 10 6 cells androgen receptor with no detectable estrogen progesterone receptor. Cells irradiated at 120 cGy/min dose rate. There was toxicity up −4 M in absence X-irradiation. At plating efficiencies from 11–13%, densities 1 × 4 60 cm 2 flask, a D o 108.5 ± 6.5, n 2.1 0.7 cGy, 143.5 1.5 2.4 0.5, respectively. addition −10 prior after, did not alter radiosensitivity. same rate cGy/min, A875 had 125 2.5 1.56 0.8 SF 0.65 0.03 line 129 4.5 1.58 0.4 0.55 0.04, radiosensitivity decrease low 5 cGy/min. Thus, vitro positive necessarily altered by presence before after irradiation. data support concept that all do show broad-shouldered curve intrinsic cellular radioresistance.
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elsevier.com参考文章(26)
Ralph C. Benson, Syed M. Hasan, Anne G. Jones, Sally Schlise, External Beam Radiotherapy for Palliation of Pain from Metastatic Carcinoma of the Prostate The Journal of Urology. ,vol. 127, pp. 69- 71 ,(1982) , 10.1016/S0022-5347(17)53609-5
M E Kaighn, Y Ohnuki, K S Narayan, L W Jones, J F Lechner, Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Investigative urology. ,vol. 17, pp. 16- 23 ,(1979)
Ralph R. Weichselbaum, John J. Nove, John B. Little, Samuel Hellman, Anthony J. Piro, Proliferation Kinetics of a Human Breast Cancer Line in Vitro following Treatment with 17β-Estradiol and 1-β-d-Arabinofuranosylcytosine Cancer Research. ,vol. 38, pp. 2339- 2342 ,(1978)
R. M. Humphrey, S. C. Barranco, M. M. Romsdahl, The Radiation Response of Human Malignant Melanoma Cells Grown in Vitro Cancer Research. ,vol. 31, pp. 830- 833 ,(1971)
Werner Hellriegel, RADIATION THERAPY OF PRIMARY AND METASTATIC MELANOMA Annals of the New York Academy of Sciences. ,vol. 100, pp. 131- 141 ,(1963) , 10.1111/J.1749-6632.1963.TB57118.X
Gordon R. Ray, J. Robert Cassady, Malcolm A. Bagshaw, Definitive Radiation Therapy of Carcinoma of the Prostate Radiology. ,vol. 106, pp. 407- 418 ,(1973) , 10.1148/106.2.407
T.J. Fitzgerald, Michael McKenna, Kenneth Kase, Cathie Daugherty, Lisa Rothstein, Joel S. Greenberger, Effect of x-irradiation dose rate on the clonagenic survival of human and experimental animal hematopoietic tumor cell lines: Evidence for heterogeneity☆ International Journal of Radiation Oncology Biology Physics. ,vol. 12, pp. 69- 73 ,(1986) , 10.1016/0360-3016(86)90417-7
BRUCE KYNASTON, THE RADIOTHERAPY OF MELANOMA Australian and New Zealand Journal of Surgery. ,vol. 48, pp. 36- 39 ,(1978) , 10.1111/J.1445-2197.1978.TB05802.X
Jay S. Cooper, Alfred W. Kopf, Robert S. Bart, Present Role and Future Prospects for Radiotherapy in the Management of Malignant Melanomas The Journal of Dermatologic Surgery and Oncology. ,vol. 5, pp. 134- 139 ,(1979) , 10.1111/J.1524-4725.1979.TB00627.X
Carlos A. Perez, Walter Bauer, Raul Garza, Robert K. Royce, Radiation therapy in the definitive treatment of localized carcinoma of the prostate Cancer. ,vol. 40, pp. 1425- 1433 ,(1977) , 10.1002/1097-0142(197710)40:4<1425::AID-CNCR2820400411>3.0.CO;2-Q