Chapter 25. Antibodies as Drug Carriers and Toxicity Reversal Agents

摘要: Publisher Summary This chapter focuses on the application of tumor specific antibodies in transporting therapeutic agents to precise target sites and anti-drug intoxicity reversal. In addition their other uses, have been used numerous diagnostic analytic operations. Antibodies carry drugs, toxins, enzymes, radioactivity, boron tissue sites, particularly treatment cancer, where employment such regimens is governed by severe constraints that arise from generally cytotoxic nature. efforts maximize ratios those previously demonstrated promising anti-tumor activities as single agents, drug-antibody complexes received major share attention. The most extensively studied complex derived chlorambucil, cytotoxic, alkylating agent reacts with biologically important nucleophiles. report enzymes could be coupled resultant retention both immunologic enzymatic was instrumental development enzyme–antibody, conjugates designed demonstrate activities. radioimmunoassay method has led routine elicitation drugs. systematic utilization reverse effects drugs more recent occurrence. Recent advent monoclonal hybridoma technique made production pure, monospecific high titer possible will a profound impact future research this area. modern protein purification techniques, use non-complement fixing, relatively non-immunogenic, rapidly excreted fab antibody fragment, establishment viable for reversing toxicity