Long-Term Results After Repeated Surgical Removal of Pulmonary Metastases

摘要: Abstract Background . Although surgical resection is accepted widely as first-line therapy for pulmonary metastases, few data exist on the treatment of recurrent metastatic disease. In a retrospective study, we analyzed patients who were operated repeatedly disease lung with curative intent over 20-year period. Methods From 1973 to 1993, 396 metastasectomies performed in 330 patients. The study population included any histologic tumor type had undergone at least two (range, 2 4) complete procedures because Surgical and functional resectability metastases control primary lesion served objective criteria reoperation. A subgroup 35 that findings such epithelial cancer osteosarcoma then was retrospectively calculate prognosis define selection repeated metastasectomy. Results 5- 10-year survival rates after first metastasectomy 48% 28%, respectively. overall median 60 months. mean disease-free interval (calculated all intervals, minimum two) greater than 1 year significantly associated advantage beyond last operation. Univariate analysis failed show size, number, increase or decrease number distribution factors related survival. Conclusions different types included, appeared be homogenous terms benefit prognostic factors, it probably represented biologically favorable tumors which histology, laterality are minor importance. We conclude persistently free location but have recurrent, resectable likely from operation second, third, even fourth time.