Structures and functions of the tumor suppressor p53.

摘要: The tumour suppressor p53 plays a crucial role in the cellular response to DNA damage. protein is able both detect sites of damage and interact with sequence-specific manner function regulation target gene expression. These two properties map discrete functional domains protein, C-terminus central core domain respectively. They are essential for integration normal damage, initiation either G1 cell cycle arrest or apoptosis. This review considers structure relation protein's various functions, together importance tertiary conformational flexibility. precise remains be established, although known phosphorylated/de-phosphorylated by number specific kinases/phosphatases. A recent discovery indicates that may activated autoproteolysis proteolytic cleavage induced direct interaction process reminiscent bacterial Lex system would provide one mechanism activation