Antiphospholipid syndrome and its role in pediatric cerebrovascular diseases: A literature review

摘要: Antiphospholipid syndrome (APS) or Hughes is an acquired thromboinflammatory disorder. Clinical criteria of APS diagnosis are large- and small-vessel thrombosis as well obstetric problems; laboratory the presence antiphospholipid antibodies (lupus anticoagulant, anticardiolipin anti-β2-glycoprotein-1). The at least 1 clinical criterion allows definitive APS. Primary diagnosed in patients without features connective tissue disease; secondary with signs autoimmune disease. A high frequency catastrophic a tendency to evolve from primary during course lupus lupus-like disease feature pediatric most characteristic presentation population venous thrombosis, mainly lower limbs, arterial causing ischemic brain stroke. Currently, no diagnostic for exist, which probably results underestimation problem. Similarly, therapeutic procedures specific children have yet been established. In present literature review, we discussed data concerning its role cerebrovascular diseases, including stroke, migraine cerebral thrombosis.