Thrombophilic gene mutations in children with migraine.
作者： M. Ferrara , L. Capozzi , F. Bertocco , D. Ferrara , R. Russo
DOI: 10.1179/102453312X13221316478010
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摘要: AbstractIn 35 patients of both sexes (18 boys and 17 girls), mean age 8.9 ± 4.5 years, affected by migraine with (45.2%) without an aura (54.9%) (P > 0.05) who had no alteration brain computerized tomography and/or magnetic resonance imaging, we evaluated possible thrombotic events in the pathogenesis disease. In all cases 50 random healthy controls clotting tests (prothrombin time, activated partial thromboplastin protein C activity (PC), antithrombin III (ATIII), S (PS), antiphospholipid antibodies (aPL), Lupus anticoagulant (LA) were normal. FVIII FIX activities increased seven five sufferers, respectively. Genetic thrombophilic risk factors – factor V Leiden (FVL) MTHFR677T resulted a significantly prevalence when compared but significant differences for F2 polymorphism. The examined polymorphisms associated developing (odds rati...
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