Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease

摘要: Background: Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN recognized as a risk factor chronic kidney disease (CKD) and end-stage renal (ESRD). It was found that significantly greater proportion of subjects with past history than without exhibited seroreactions to antigens called inhibitor complement (SIC) distantly related SIC (DRS). These are expressed by major PSGN-associated GAS types. We therefore predicted in such India, which endemic diseases has high prevalence CKD ESRD, proportions ESRD patients exhibit seroreaction DRS healthy controls. Methods: To test this we conducted seroprevalence study from Mumbai area. recruited 100 CKD, 70 individuals. Results: Nineteen 35.7% respectively were antibody-positive, whereas only 7% cohort seropositive SIC. Furthermore, (p=0.02; odds ratio 2.37). No association between DRS-antibody-positivity. Conclusions: Past infection SIC-positive population. seropositivity predictive poor prognosis patients.