Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia

摘要: BACKGROUND. The aim of this study was to determine whether antibiotic prophylaxis during periods neutropenia reduced streptococcal (S. viridans) sepsis and overall bacterial sepsis. METHODS. The authors reviewed outcomes 78 evaluable patients who were consecutively treated for acute myeloid leukemia (AML) from October 2002 through January 2007. Several successive prophylactic regimens used. All received antifungal with oral voriconazole. RESULTS. Oral cephalosporins did not significantly reduce the odds (P = .81) or .90) relative no prophylaxis. Intravenous (iv) cefepime completely prevented 91% < .0001) prophylaxis, but resistant gram-negative bacteria emerged in 2 patients. Vancomycin ciprofloxacin a cephalosporin by 93% 99% .0001). The fungal infection rate differ between receive (1.0 per 1000 patient-days both groups). observed reduction average hospital days chemotherapy course given vancomycin 5.7 4.1 .0039) days, respectively. No .10). Furthermore, associated 20% healthcare charges .0015) using antibiotics. One patient, on cefuroxime alone, died septicemia. CONCLUSIONS. Prophylaxis intravenous regimen, voriconazole, morbidity children AML, resulted indramatic decreases incidence septicemia hospitalization days. Cancer 2008. © 2008 American Society.