Severe infections in children with acute leukemia undergoing intensive chemotherapy can successfully be prevented by ciprofloxacin, voriconazole, or micafungin prophylaxis.
作者： Ting‐Chi Yeh , Hsi‐Che Liu , Jen‐Yin Hou , Kuan‐Hao Chen , Ting‐Huan Huang
DOI: 10.1002/CNCR.28524
关键词:
摘要: BACKGROUND The purpose of the current study was to prevent bloodstream infection and invasive fungal (IFI) by administering prophylactic antibiotic antifungal agents during intensive chemotherapy in patients being treated for acute leukemia. METHODS Prophylaxis treatment administered children with myeloid leukemia (AML) lymphoblastic (ALL) from January 1, 2010 December 31, 2012. Oral ciprofloxacin (at a dose 300 mg/m2/12 hours) after when patient AML or ALL became neutropenic and > 7 days neutropenia expected. Voriconazole 4 mg/kg/12 initiated at onset 7 ALL. Micafungin 2 mg/kg/day) substituted voriconazole received vincristine. Prophylaxis discontinued absolute neutrophil count recovered to > 100/μL. All episodes infection, IFI, febrile neutropenia, care unit stays related severe occurring between 2005 2012 were recorded. RESULTS During preprophylaxis period, 62 24 experienced total 44 22 IFI. Seven died infection. In contrast, prophylaxis 10 occurred no IFIs reported occur 51 14 AML. Moreover, Episodes stay significantly reduced period. CONCLUSIONS Prophylaxis micafungin found reduce rates IFI undergoing chemotherapy. Cancer 2014;120:1255–1262. © 2014 American Society.
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